Lifespark Eradication Mill

[Bilygote]

{Lifespark Spellbomb} + {Eradicate} + any unblockable creature equipped with {Trepanation Blade} = milled opponent + big damage

[BlackJester]

You had me at {Lifespark } + {Eradicate}.   

The {Trepanation Blade} is some serious icing on that cake of pain.
{Mind Funeral} would be a nice cherry too.
Mono-colored decks, beware!

[Grexis]

I use the blade with {invisible stalker} in my mill deck it's pretty awesome especially if ya got {mindcrank} out