Pestilence

[Subiskier]

{pestilence} + {high priest of penance} + anything that boosts his toughness like {honor of the pure} = 1 mana kills of any non land permanent

Add in {wall of hope} to neutralize your life loss and some other fun combos and its all downhill from there

[KILLERBEE]

You could just give the  {High Priest of Penance}  {Darksteel Plate}, then ping it with  {Pestilence},  {Olivia Voldaren}, or anything else. That way you could do it any number of times per turn and not have to worry about him being a 3/3 or 1/2 or etc.

[Double-O-Scotch]

{pestilence} and {death Pitts of rath}

[rarehuntertay]

 {Bad Moon}

[MarduArrow]

 {Pestilence}+ {Parallel Lives}+ {Sprouting Phytohydra}