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I believe that + counters and - counters are treated as modifiers to a single total counter on a permanent.  Such that a permanent. Annoy have +2/+2 and a -1/-1; it would just be the sum; +1+1.

In the case of undying and infect, Wizard addresses this specifically.  If the the creature EVER had + permanents on it... It don't come back.

MSG prompt would be nice as stated above.  In constructed anywhere from 1 to 4 is all common... Only your key cards are 4 ofs.